PREFACE During a brief visit to Java in January 1969 I was impressed by the number of men in the hospitals with peripheral arterial disease of the four limb youthful type. It was being diagnosed by Indonesian doctors ...

Varicose veins are an extremely common condition, with significant challenges in regard to the best approach to the management of incompetent venous perforators. In order to better understand the role of the venous perforator ...

Background: Matrix metalloproteinases (MMPs) and the tissue inhibitors of matrix metalloproteinases (TIMPs) are involved in remodelling the extracellular matrix of the vascular system. Altered MMP expression has been ...

Background: Abdominal aortic aneurysm (AAA) is a life-threatening disease with a strong genetic component that predominantly affects elderly males. Previous genome-wide association studies (GWAS) have identified a number ...

This thesis examines two concepts that impact on surgical complications – prediction and prevention. The starting point was a randomised controlled trial (RCT) which compared the frequency and the cost of infection for two ...

Decision making is a key competency for surgeons and trainees; however, neither its key components, nor how it should be taught and assessed, are well understood in all surgical settings. Most surgical decision making ...