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Search Results for Division/School: Department of Biochemistry
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(Thesis, Master of Science, 2011)Wilms’ tumour is a paediatric nephroblastoma which affects 1: 10,000 live births, and is the most common form of solid tumour in children under 5 years of age. Approximately 10-20% of cases have a mutated wt1 gene. Wilms’ ... -
(Thesis, Doctor of Philosophy, 2013)Colorectal cancer (CRC) is proposed to originate through three major molecular pathways, chromosomal instability (CIN), microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Many studies have ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2012)Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome caused by germline mutations in the CDH1 gene which encodes the calcium-dependent, cell-cell adhesion protein E-cadherin [1,2]. Early stage ... -
(Thesis, Master of Science, 2012)The PAX gene family encodes a group of transcription factors that play important roles during embryogenesis with mutations resulting in developmental abnormalities. Normally expression of these genes is downregulated prior ... -
(Thesis, Doctor of Philosophy, 2007)Aberrant cell proliferation is a fundamental feature of cancer. It is thus not unexpected that many studies have been devoted to the exploration of tumour cell proliferation as a potential indicator of outcome. Indeed, in ...
Now showing items 1-5 of 5