Otago University Research Archive
Browsing Pathology - Christchurch by Date Published
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Browsing Pathology - Christchurch by Date Published
Now showing items 1-14 of 14
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(Thesis, Doctor of Philosophy, 2013)Cancer cells within a solid tumour are often under considerable metabolic stress, which would normally signal cell death. However, cancer cells are able to adapt and survive their inhospitable microenvironment by activating ... -
(Thesis, Doctor of Philosophy, 2013)Streptococcus pneumoniae (the pneumococcus) is one of the most important bacterial pathogens and contributes extensively to global infectious disease morbidity and mortality, especially in children. To unequivocally identify ... -
(Thesis, Doctor of Philosophy, 2012)A. fumigatus is the principle cause of fatal invasive pulmonary aspergillosis (IPA) in severely immunocompromised hosts and rapid treatment is compromised by the limitations in the current diagnostic tests. 2-pentylfuran ... -
(Thesis, Doctor of Philosophy, 2011)When neutrophils phagocytose bacteria, myeloperoxidase generates the cytotoxic agent HOCl. However, debate exists as to whether HOCl is the major contributor to bacterial killing. Several studies have demonstrated that ... -
(Thesis, Master of Medical Laboratory Science, 2011)The species designation Streptococcus pseudopneumoniae has recently been proposed for a streptococcus that is phenotypically and genetically distinct from Streptococcus pneumoniae and other viridans streptococci. The key ... -
(Thesis, Doctor of Philosophy, 2011)A link between obesity and risk of colorectal cancer development is strongly supported by epidemiological studies. Several obesity-related factors are implicated in this relationship. Among them, insulin resistance, a ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Macrophage migration inhibitory factor (MIF) is a highly conserved regulatory cytokine, known to exert pro-inflammatory effects. MIF biological activity is primarily regulated via interaction with the CD74 receptor. MIF ...
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(Thesis, Doctor of Philosophy, 2011)Myocardial ischemia is associated with coronary artery disease. Prolonged ischemia may lead to loss of viability of myocardial cells and reperfusion is imperative for the reversal of changes. However, reperfusion is ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Abstract Inflammatory Bowel Disease (IBD) is an inflammatory condition in which neutrophils play an important role. Colonoscopy with biopsy is thought to be the best method for evaluating inflammation location, extent, ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Telomeres are specialised structures, consisting of tracts of simple DNA sequence repeats that cap the ends of chromosomes. These structures play a vital role in maintaining the integrity of the genome and prevent the loss ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Endogenous hydrogen sulfide (H2S) has recently been described as the third gaseous mediator of interest. It has been proposed in the literature [1] , that H2S has a role in inflammation, through the induction of upstream ...
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(Thesis, Doctor of Philosophy, 2011)Methamphetamine is an illicit psychoactive stimulant with a high abuse liability. Addiction to methamphetamine creates a significant burden on public services and a considerable cost to society. It is a complex disorder ...
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(Thesis, Doctor of Philosophy, 2011)The neutrophil oxidative burst during inflammation is a main source of oxidants in vivo. As a result of neutrophil activation, the inflammatory oxidants produced include H2O2 and chlorinated oxidants (HOCl and chloramines). ... -
(Thesis, Doctor of Philosophy, 2006)Aim To develop assays for the determination of functional vitamin status and to determine the functional vitamin status of an elderly population. Specifically the focus has been to develop assays to measure the biological ...
Now showing items 1-14 of 14