Otago University Research Archive
Browsing Physiology by Date Published
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Browsing Physiology by Date Published
Now showing items 1-20 of 29
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Cardiac function and β-adrenergic receptor responsiveness in the isolated human diabetic myocardium (Thesis, Bachelor of Biomedical Sciences with Honours, 2012)The prevalence of type 2 diabetic mellitus is closely associated with cardiovascular complications. Diabetic patients with preserved ejection fraction (EF) are at high risk of developing heart failure. Until now, little ...
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(Thesis, Doctor of Philosophy, 2012)Abstract The primary aim of this thesis was to describe the dynamic response characteristics of leg blood flow (LBF) and leg vascular conductance (LVC) during exercise and recovery, and to investigate the influence of ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2012)Polycystic ovarian syndrome (PCOS) is the most common cause of infertility among women of reproductive age worldwide. Although the aetiology is unclear, there are a number of neuroendocrine disruptions which identify PCOS ... -
(Thesis, Master of Science, 2012)The neuronal voltage gated Ca2+ channel CaV2.1, regulates neurotransmitter release. Recently, the E1015K polymorphism was identified in the SNARE interaction synprint site of CaV2.1 in migraine patients. In this study, we ...
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(Thesis, Doctor of Philosophy, 2012)In the intestine of eutherian mammals, such as human, rabbit, rat and mouse, fluid secretion is primarily driven by Cl- transport. However, in the ileum of possum (Trichosurus vulpecula), a metatherian mammal, the fluid ...
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(Thesis, Doctor of Philosophy, 2012)Gonadotropin-releasing hormone (GnRH) neurons are the final output neurons of a hypothalamic network controlling fertility in mammals. They release GnRH from axon terminals into the portal blood circulation of the pituitary, ...
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(Thesis, Doctor of Philosophy, 2012)Rheumatoid arthritis (RA) is an, autoimmune disease where genetic predisposition and environmental factors increase the risk of developing RA and the severity of the disease. Cigarette smoking is the major recognised ...
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(Thesis, Doctor of Philosophy, 2012)The gonadotropin-releasing hormone (GnRH) neurons, located within the hypothalamus of the mammalian brain, have been established as the key output cells mediating all influences that control fertility, conveyed by the ...
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(Thesis, Doctor of Philosophy, 2012)Reproduction and fertility in mammals is critically dependent on the neurosecretion of gonadotrophin-releasing hormone (GnRH) released by the hypothalamic GnRH neurons into the hypophyseal portal system of the anterior ...
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(Thesis, Doctor of Philosophy, 2011)The receptor for advanced glycation end products (RAGE) is a cell surface signal transduction receptor that amplifies inflammation, principally through the activation of nuclear factor (NF)-κB. A circulating soluble form ...
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(Thesis, Doctor of Philosophy, 2011)The process of liver regeneration after partial hepatectomy is very complex and is associated with signalling cascades involving initiation signals, transcription factors, cytokines, growth factors, tissue remodelling and ...
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(Thesis, Doctor of Philosophy, 2011)Epilepsy affects around 1 % of the population, and up to a third of patients are resistant to antiepileptic drugs (AEDs). Epilepsy is defined as an enduring predisposition of the brain to generate seizures, and the disorder ...
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(Thesis, Doctor of Philosophy, 2011)The cerebellum has often been referred to as the "neuronal machine", so called for the elegant architecture of neuronal circuitry and necessarily clockwork precision of signal transmission therein (Eccles 1967; Ito 2006). ...
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(Thesis, Doctor of Philosophy, 2011)The basal forebrain cholinergic (BFC) system is one of the most important neurotransmitter systems in the brain. It has received much attention in the past two decades, primarily for its role in learning, memory, attention ... -
(Thesis, Bachelor of Medical Science with Honours, 2011)The hormone oxytocin is secreted from nerve terminals of oxytocin magnocellular cells (MNCs) in the posterior pituitary gland and is important in the timing of birth and is essential for milk secretion. Another reproductive ... -
(Thesis, Doctor of Philosophy, 2011)Spinal cord injury (SCI) is a debilitating disorder, causing cardiovascular dysfunction at rest and during orthostasis [as simulated by lower-body negative pressure (LBNP)], which differs with the level, completeness, and ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Abstract Increased cardiac sympathetic drive as a consequence of increased renal sympathetic activity is an important contributor to the development of cardiovascular complications in patients with diabetic nephropathy. ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)The cerebellum performs a well-known motor control function but accumulating evidence supports its role in cognitive functions. The nicotinic cholinergic system alters cognition through its actions elsewhere in the brain ...
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(Thesis, Doctor of Philosophy, 2011)The extent to which systemic hypoxia may compromise cerebrovascular function is likely to depend on the intensity and duration of the hypoxic insult. This thesis presents four studies that used a range of intermittent and ...
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(Thesis, Doctor of Philosophy, 2011)The maintenance of adequate cerebral blood flow (CBF) is important both acutely and chronically, is highly dependent on mean arterial pressure (MAP) and the partial pressure of arterial carbon dioxide (PaCO2), and can be ...
Now showing items 1-20 of 29