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Search Results for Collection: Pharmacology and Toxicology

Now showing items 1-10 of 10

Novel drug therapies for ER- basal-like breast cancer; preclinical evaluation in a xenograft model.

Scandlyn, Marissa Jayne (Thesis, Doctor of Philosophy, 2011)

Basal-like breast cancers are a subgroup of breast lesions that are triple-negative for the estrogen receptor (ER), progesterone receptor and human epidermal growth factor receptor 2. There is currently no effective treatment ...
Carbon Monoxide and Hypothermic Pulsatile Perfusion in Renal Transplantation

Winburn, Ian (Thesis, Doctor of Philosophy, 2011)

Chronic kidney disease is a highly prevalent condition and renal transplantation is the definitive treatment for those with end stage renal failure. This life saving treatment is unfortunately hindered by a shortage of ...
Examination of the Hypothalamic Paraventricular Nucleus in a Rat Model of Chronic Ischaemic Myocardial Injury

Kelly, Jessica Renee (Thesis, Master of Science, 2011)

Ischaemic heart disease, including heart failure (HF) is a leading cause of death worldwide. Despite pharmacological intervention, HF remains a progressive disease with a high mortality rate. The role of the central nervous ...
Neuroinflammation and Cannabinoid CB2 Receptor Expression in the Human Huntington's Disease Brain and R6/1 Transgenic Mouse Model

Hoffman, Therri (Thesis, Master of Science, 2012)

Neuroinflammation is recognised as a common feature of the pathological disease process in a number of chronic neurodegenerative conditions including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and ...
Synthetic Cannabinoids as a Novel Treatment for Triple Negative Breast Cancer

Tran, Khanh Bao (Thesis, Master of Science, 2011)

Approximately one in five breast cancer patients exhibits triple negative tumors that are characterized by the lack of estrogen receptor (ER), progesterone receptor and HER2. While ER and HER2 positive tumors are responsive ...
The Oxidative Modifications to Cancer Cells Induced by Three Redox-Active Drugs: Auranofin, PEITC and TDSNO

Deuss, Felix (Thesis, Master of Science, 2012)

Redox homeostasis is of critical importance for normal cellular functions. The intracellular environment is maintained in a reduced state, upon which, reactive oxygen (ROS) and nitrogen (RNS) species oxidise cellular ...
Chronic Bilateral Renal Denervation in Experimental Diabetic Nephropathy

Yao, Yimin (Thesis, Doctor of Philosophy, 2012)

Chronic bilateral renal denervation (BRD) has been shown to reduce systemic blood pressure and improve insulin sensitivity and renal function in both human and experimental animal models. However, the effect of chronic BRD ...
Poppy seed tea : preparation, composition and effects of a legal high

Wilson, Nicholas Mark (Thesis, Master of Science, 2005)
Acute mortality related to prescription and illicit drug overdose in New Zealand from 1998 to 2001

Morgan, Elizabeth Danuta (Thesis, Master of Science, 2003)
Raloxifene along with curcumin analogue RL91, a combinational approach against hormone refractory prostate cancer

Mazumder, Aloran (Thesis, Master of Science, 2013)

Background: Approximately 80% of prostate cancer patients undergoing hormone therapy progress within 12-18 months to a hormone insensitive form of the disease known as hormone refractory prostate cancer. The median survival ...

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