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Search Results for Collection: Pharmacology and Toxicology

Now showing items 1-9 of 9

Raloxifene for the Treatment of Triple Negative Breast Cancer

Dzeyk, Julian (Thesis, Master of Science, 2012)

Triple negative breast cancer (TNBC) represents a subgroup of mammary cancers associated with particularly poor prognosis as they are refractory to currently available targeted therapy used to treat other breast cancers. ...
Neuroinflammation and Cannabinoid CB2 Receptor Expression in the Human Huntington's Disease Brain and R6/1 Transgenic Mouse Model

Hoffman, Therri (Thesis, Master of Science, 2012)

Neuroinflammation is recognised as a common feature of the pathological disease process in a number of chronic neurodegenerative conditions including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and ...
Crosstalk Between Iron Homeostasis And Nitric Oxide Signalling: Impact On Cancer Cell Viability

Ariffin, Mimi (Thesis, Master of Science, 2012)

The element iron (Fe) is essential for mammals since many enzymes require Fe as a cofactor for metabolic processes. Fe regulation is extremely important to maintain Fe homeostasis as Fe overload and Fe deprivation are ...
The effect of anxiolytic and anxiogenic drugs on spatial memory and anxiety-related behaviours in bilateral vestibular deafferented rats

Cheung, Irene Cheuk-Wai (Thesis, Master of Science, 2012)

Vestibular dysfunction in humans is associated with a high rate of anxiety and depressive disorders. Although this may first appear to be due to the burden of living with a balance disorder, there is reason to think that ...
Study of New Curcumin Analogs for the Treatment of Erα Negative Breast Cancers

Yadav, Babasaheb Dattatraya (Thesis, Doctor of Philosophy, 2012)

Breast cancer is the most prevalent form of cancer diagnosed in women, and there continues to be limited drug treatment options for the ~30% of patients with estrogen receptor (ERα)-negative breast cancers. In the search ...
The cannabinoid CB2 receptor as a target for the treatment of neuropathic pain

Brownjohn, Philip William (Thesis, Doctor of Philosophy, 2012)

Cannabinoids are cannabis-like drugs that are moderately efficacious in the treatment of some types of chronic pain, including pain of a neuropathic origin. Limiting their therapeutic application, however, are adverse ...
Cardiac Injury during Kainic Acid Induced Seizures: Effects of Gender on ECG

Read, Morgayn Iona (Thesis, Master of Science, 2012)

Epilepsy is associated with an increased mortality rate. In 7 to 17% of epileptics, the cause of death is unknown and this has been termed sudden unexplained death in epilepsy (SUDEP). Seizure-induced cardiac changes have ...
The Oxidative Modifications to Cancer Cells Induced by Three Redox-Active Drugs: Auranofin, PEITC and TDSNO

Deuss, Felix (Thesis, Master of Science, 2012)

Redox homeostasis is of critical importance for normal cellular functions. The intracellular environment is maintained in a reduced state, upon which, reactive oxygen (ROS) and nitrogen (RNS) species oxidise cellular ...
Chronic Bilateral Renal Denervation in Experimental Diabetic Nephropathy

Yao, Yimin (Thesis, Doctor of Philosophy, 2012)

Chronic bilateral renal denervation (BRD) has been shown to reduce systemic blood pressure and improve insulin sensitivity and renal function in both human and experimental animal models. However, the effect of chronic BRD ...