Otago University Research Archive
Browsing Pharmacology and Toxicology by Date Published
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Browsing Pharmacology and Toxicology by Date Published
Now showing items 1-20 of 24
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(Thesis, Master of Science, 2013)VEGF (Vascular endothelial growth factor)-A has been shown to successfully enter the brain via the intranasal pathway and improve symptoms following focal ischemia in rats. However VEGF-A promotes inflammation and vascular ... -
(Thesis, Master of Science, 2013)Background: Approximately 80% of prostate cancer patients undergoing hormone therapy progress within 12-18 months to a hormone insensitive form of the disease known as hormone refractory prostate cancer. The median survival ...
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(Thesis, Doctor of Philosophy, 2013)Global ischaemia during cardiac surgery, brain surgery and stroke frequently leads to neuronal injury and lasting neuropsychological dysfunction. Experimental preconditioning provides beneficial cerebral outcomes in these ... -
(Thesis, Master of Science, 2012)Epilepsy is associated with an increased mortality rate. In 7 to 17% of epileptics, the cause of death is unknown and this has been termed sudden unexplained death in epilepsy (SUDEP). Seizure-induced cardiac changes have ... -
(Thesis, Master of Science, 2012)Triple negative breast cancer (TNBC) represents a subgroup of mammary cancers associated with particularly poor prognosis as they are refractory to currently available targeted therapy used to treat other breast cancers. ... -
(Thesis, Master of Science, 2012)Redox homeostasis is of critical importance for normal cellular functions. The intracellular environment is maintained in a reduced state, upon which, reactive oxygen (ROS) and nitrogen (RNS) species oxidise cellular ...
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(Thesis, Doctor of Philosophy, 2012)Chronic bilateral renal denervation (BRD) has been shown to reduce systemic blood pressure and improve insulin sensitivity and renal function in both human and experimental animal models. However, the effect of chronic BRD ...
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(Thesis, Master of Science, 2012)The element iron (Fe) is essential for mammals since many enzymes require Fe as a cofactor for metabolic processes. Fe regulation is extremely important to maintain Fe homeostasis as Fe overload and Fe deprivation are ... -
(Thesis, Master of Science, 2012)Vestibular dysfunction in humans is associated with a high rate of anxiety and depressive disorders. Although this may first appear to be due to the burden of living with a balance disorder, there is reason to think that ... -
(Thesis, Doctor of Philosophy, 2012)Breast cancer is the most prevalent form of cancer diagnosed in women, and there continues to be limited drug treatment options for the ~30% of patients with estrogen receptor (ERα)-negative breast cancers. In the search ... -
(Thesis, Master of Science, 2012)Neuroinflammation is recognised as a common feature of the pathological disease process in a number of chronic neurodegenerative conditions including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and ...
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(Thesis, Doctor of Philosophy, 2012)Cannabinoids are cannabis-like drugs that are moderately efficacious in the treatment of some types of chronic pain, including pain of a neuropathic origin. Limiting their therapeutic application, however, are adverse ... -
(Thesis, Master of Science, 2011)Approximately one in five breast cancer patients exhibits triple negative tumors that are characterized by the lack of estrogen receptor (ER), progesterone receptor and HER2. While ER and HER2 positive tumors are responsive ...
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Novel drug therapies for ER- basal-like breast cancer; preclinical evaluation in a xenograft model. (Thesis, Doctor of Philosophy, 2011)Basal-like breast cancers are a subgroup of breast lesions that are triple-negative for the estrogen receptor (ER), progesterone receptor and human epidermal growth factor receptor 2. There is currently no effective treatment ...
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(Thesis, Master of Science, 2011)Cardiovascular disease is the leading killer within the western world. Direct pathological interactions have been shown to exist between cardiovascular disease, and the development of renal disease, and vice versa. This ... -
(Thesis, Doctor of Philosophy, 2011)Chronic kidney disease is a highly prevalent condition and renal transplantation is the definitive treatment for those with end stage renal failure. This life saving treatment is unfortunately hindered by a shortage of ...
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(Thesis, Master of Science, 2011)Increased locomotor activities as well as circling behaviours in animals with bilateral vestibular loss are well documented in the literature. However, the cause of these behavioural changes are still unknown. Dysfunction ... -
(Thesis, Master of Science, 2011)Dysfunction of the vestibular system can be caused by a number of conditions including Meniere‘s disease and aminoglycoside antibiotic induced damage. Bilateral vestibular damage results in symptoms such as vertigo, ... -
(Thesis, Doctor of Philosophy, 2011)Stroke is a major cause of death and the highest cause of morbidity worldwide. In NZ, the elderly and Maori and Pacific Island ethnicities are most affected. With failure of many neuroprotectant agents, current clinical ... -
(Thesis, Master of Science, 2011)Ischaemic heart disease, including heart failure (HF) is a leading cause of death worldwide. Despite pharmacological intervention, HF remains a progressive disease with a high mortality rate. The role of the central nervous ...
Now showing items 1-20 of 24