Otago University Research Archive
Browsing Pharmacology and Toxicology by Title
Otago University Research Archive
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Browsing Pharmacology and Toxicology by Title
Now showing items 15-23 of 23
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(Thesis, Doctor of Philosophy, 2011)Stroke is a major cause of death and the highest cause of morbidity worldwide. In NZ, the elderly and Maori and Pacific Island ethnicities are most affected. With failure of many neuroprotectant agents, current clinical ... -
(Thesis, Master of Science, 2012)Neuroinflammation is recognised as a common feature of the pathological disease process in a number of chronic neurodegenerative conditions including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and ...
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Novel drug therapies for ER- basal-like breast cancer; preclinical evaluation in a xenograft model. (Thesis, Doctor of Philosophy, 2011)Basal-like breast cancers are a subgroup of breast lesions that are triple-negative for the estrogen receptor (ER), progesterone receptor and human epidermal growth factor receptor 2. There is currently no effective treatment ...
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(Thesis, Master of Science, 2012)Redox homeostasis is of critical importance for normal cellular functions. The intracellular environment is maintained in a reduced state, upon which, reactive oxygen (ROS) and nitrogen (RNS) species oxidise cellular ...
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(Thesis, Doctor of Philosophy, 2013)Global ischaemia during cardiac surgery, brain surgery and stroke frequently leads to neuronal injury and lasting neuropsychological dysfunction. Experimental preconditioning provides beneficial cerebral outcomes in these ... -
(Thesis, Master of Science, 2005)
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(Thesis, Master of Science, 2012)Triple negative breast cancer (TNBC) represents a subgroup of mammary cancers associated with particularly poor prognosis as they are refractory to currently available targeted therapy used to treat other breast cancers. ... -
(Thesis, Doctor of Philosophy, 2012)Breast cancer is the most prevalent form of cancer diagnosed in women, and there continues to be limited drug treatment options for the ~30% of patients with estrogen receptor (ERα)-negative breast cancers. In the search ... -
(Thesis, Master of Science, 2011)Approximately one in five breast cancer patients exhibits triple negative tumors that are characterized by the lack of estrogen receptor (ER), progesterone receptor and HER2. While ER and HER2 positive tumors are responsive ...
Now showing items 15-23 of 23