Otago University Research Archive
Browsing Pharmacology and Toxicology by Date Added
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Browsing Pharmacology and Toxicology by Date Added
Now showing items 1-20 of 24
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(Thesis, Master of Science, 2013)Background: Approximately 80% of prostate cancer patients undergoing hormone therapy progress within 12-18 months to a hormone insensitive form of the disease known as hormone refractory prostate cancer. The median survival ...
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(Thesis, Doctor of Philosophy, 2013)Global ischaemia during cardiac surgery, brain surgery and stroke frequently leads to neuronal injury and lasting neuropsychological dysfunction. Experimental preconditioning provides beneficial cerebral outcomes in these ... -
(Thesis, Master of Science, 2013)VEGF (Vascular endothelial growth factor)-A has been shown to successfully enter the brain via the intranasal pathway and improve symptoms following focal ischemia in rats. However VEGF-A promotes inflammation and vascular ... -
(Thesis, Master of Science, 2005)
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Acute mortality related to prescription and illicit drug overdose in New Zealand from 1998 to 2001 (Thesis, Master of Science, 2003)
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(Thesis, Doctor of Philosophy, 2012)Chronic bilateral renal denervation (BRD) has been shown to reduce systemic blood pressure and improve insulin sensitivity and renal function in both human and experimental animal models. However, the effect of chronic BRD ...
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(Thesis, Master of Science, 2012)Redox homeostasis is of critical importance for normal cellular functions. The intracellular environment is maintained in a reduced state, upon which, reactive oxygen (ROS) and nitrogen (RNS) species oxidise cellular ...
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(Thesis, Master of Science, 2012)Triple negative breast cancer (TNBC) represents a subgroup of mammary cancers associated with particularly poor prognosis as they are refractory to currently available targeted therapy used to treat other breast cancers. ... -
(Thesis, Master of Science, 2012)Epilepsy is associated with an increased mortality rate. In 7 to 17% of epileptics, the cause of death is unknown and this has been termed sudden unexplained death in epilepsy (SUDEP). Seizure-induced cardiac changes have ... -
(Thesis, Doctor of Philosophy, 2012)Cannabinoids are cannabis-like drugs that are moderately efficacious in the treatment of some types of chronic pain, including pain of a neuropathic origin. Limiting their therapeutic application, however, are adverse ... -
(Thesis, Master of Science, 2012)Neuroinflammation is recognised as a common feature of the pathological disease process in a number of chronic neurodegenerative conditions including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and ...
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(Thesis, Master of Science, 2011)Approximately one in five breast cancer patients exhibits triple negative tumors that are characterized by the lack of estrogen receptor (ER), progesterone receptor and HER2. While ER and HER2 positive tumors are responsive ...
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(Thesis, Doctor of Philosophy, 2012)Breast cancer is the most prevalent form of cancer diagnosed in women, and there continues to be limited drug treatment options for the ~30% of patients with estrogen receptor (ERα)-negative breast cancers. In the search ... -
(Thesis, Master of Science, 2012)The element iron (Fe) is essential for mammals since many enzymes require Fe as a cofactor for metabolic processes. Fe regulation is extremely important to maintain Fe homeostasis as Fe overload and Fe deprivation are ... -
(Thesis, Master of Science, 2012)Vestibular dysfunction in humans is associated with a high rate of anxiety and depressive disorders. Although this may first appear to be due to the burden of living with a balance disorder, there is reason to think that ... -
(Thesis, Master of Science, 2011)Tinnitus is characterised by a phantom ringing in the ear. Approximately twelve million Americans experience tinnitus in a form severe enough to require medical attention. Despite this prevalence there is no effective ... -
(Thesis, Master of Science, 2011)Ischaemic heart disease, including heart failure (HF) is a leading cause of death worldwide. Despite pharmacological intervention, HF remains a progressive disease with a high mortality rate. The role of the central nervous ...
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(Thesis, Doctor of Philosophy, 2011)Stroke is a major cause of death and the highest cause of morbidity worldwide. In NZ, the elderly and Maori and Pacific Island ethnicities are most affected. With failure of many neuroprotectant agents, current clinical ... -
(Thesis, Master of Science, 2011)Dysfunction of the vestibular system can be caused by a number of conditions including Meniere‘s disease and aminoglycoside antibiotic induced damage. Bilateral vestibular damage results in symptoms such as vertigo, ... -
(Thesis, Master of Science, 2011)Increased locomotor activities as well as circling behaviours in animals with bilateral vestibular loss are well documented in the literature. However, the cause of these behavioural changes are still unknown. Dysfunction ...
Now showing items 1-20 of 24