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Search Results for Collection: Microbiology and Immunology
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(Thesis, Master of Science, 2012)A strain of Micrococcus luteus, isolated from the epidermis of an adult human male, produces anti-bacterial activity in vitro. The purpose of this study was to investigate the potential value of this bacterium, designated ...
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(Thesis, Doctor of Philosophy, 2011)Quorum-sensing is a system where genes are regulated in response to changing cell density by the synthesis, release and detection of a signalling molecule to facilitate the coordination of group behaviour such as in the ...
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(Thesis, Master of Science, 2011)Streptococcus salivarius are numerically predominant bacteria in the human oral cavity and are generally located on the tongue dorsum. Some strains have been shown to produce megaplasmid-encoded lantibiotics that antagonise ...
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(Thesis, Master of Science, 2010)Periodontitis is a disease that is characterised by inflammation of the gums and subsequent loss of teeth which affects up to 57% of the world’s population. Key pathogens implicated in periodontitis include Porphyromonas ...
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(Thesis, Doctor of Philosophy, 2005)Johne's disease in ruminants is caused by the pathogenic bacterium Mycobacterium avium subspecies paratuberculosis. An experimental infection model in sheep was developed as a prelude to the testing of new vaccines and the ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)p53 is a crucial tumour suppressor, as evidenced by three important observations: p53 is lost or mutated in half of all human cancers, an inheritable p53 mutation predisposes to an early onset of multiple cancer types, and ...
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(Thesis, Doctor of Philosophy, 2011)The primary risk factor for the development of cervical cancer is a persistent infection with certain high-risk human papillomavirus (HPV) types such as 16 and 18. The ability of these viruses to cause such persistent ...
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(Thesis, Doctor of Philosophy, 2011)The genome of Mycobacterium smegmatis contains three putative toxin-antitoxin (TA) systems. The vapBC system has been characterized, but the remaining two TA systems, belonging to the mazEF and phd/doc family have not been ...
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(Thesis, Master of Science, 2012)One contentious method by which bacteria deal with a maladapted situation is what has been coined ‘adaptive’, ‘directed’ or ‘stress induced-mutation’. This involves mutants that compensate for some form of sub-lethal stress ... -
(Thesis, Doctor of Philosophy, 2011)Poxviruses are large DNA viruses that replicate in the cytoplasm, and encode numerous host immune modulating factors. The parapoxvirus, orf virus (ORFV) is a zoonotic pathogen that causes pustular dermatitis in sheep, goats ...