Otago University Research Archive
Browsing Otago School of Medical Sciences by Date Published
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Browsing Otago School of Medical Sciences by Date Published
Now showing items 1-20 of 237
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(Thesis, Master of Science, 2013)Mitochondrial DNA (mtDNA) is commonly used in population and evolutionary genetics due to its unique characteristics, such as maternal inheritance and a lack of recombination. Increasing reports of paternal inheritance ...
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(Thesis, Doctor of Philosophy, 2013)Global ischaemia during cardiac surgery, brain surgery and stroke frequently leads to neuronal injury and lasting neuropsychological dysfunction. Experimental preconditioning provides beneficial cerebral outcomes in these ... -
(Thesis, Master of Science, 2013)The objective of this research was to determine whether the Type IV pili of Synechocystis sp. PCC 6803 are involved in electron donation to the extracellular environment. In conjunction with the current theories and published ...
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(Thesis, Doctor of Philosophy, 2013)Prolactin is a physiologically important hormone with multiple actions. Its secretion from the anterior pituitary is regulated by dopamine secretion from the tuberoinfundibular dopaminergic (TIDA) neurons located in the ...
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(Thesis, Master of Science, 2013)Leptin, an adipose-derived anorectic hormone, modulates a number of hypothalamic functions including a permissive regulation of fertility. Leptin ‘sends’ information to the hypothalamic gonadotrophin-releasing hormone ...
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(Thesis, Master of Science, 2013)VEGF (Vascular endothelial growth factor)-A has been shown to successfully enter the brain via the intranasal pathway and improve symptoms following focal ischemia in rats. However VEGF-A promotes inflammation and vascular ... -
(Thesis, Doctor of Philosophy, 2013)The striatum, the major input structure of the basal ganglia in the brain, and the superior colliculus (SC) play distinct roles in reinforcement learning. With training, tonically active neurons (TANs) in the striatum ...
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(Thesis, Doctor of Philosophy, 2013)Colorectal cancer (CRC) is proposed to originate through three major molecular pathways, chromosomal instability (CIN), microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Many studies have ...
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(Thesis, Master of Science, 2013)People carrying the Lapita culture, which first appeared in the Bismarck archipelago c. 3300 BP, were the first colonists of Remote Oceania. While over 200 Lapita sites have been identified throughout the Pacific, very few ...
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(Thesis, Doctor of Philosophy, 2013)Infectious disease accounts for the highest percentage of preventable deaths worldwide and today’s health care systems are predominately reliant upon antibiotics to treat bacterial infections bacterial strains. Serious ... -
(Thesis, Doctor of Philosophy, 2013)The immune system has the potential to detect and destroy tumour cells, however naturally occurring anti-tumour immunity is not always capable of controlling tumour growth. Immunotherapy can harness the anti-tumour function ...
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(Thesis, Master of Science, 2013)Honeybees (Apis mellifera) are remarkable creatures with a complex eusocial hive structure. There are two female honeybee castes within a hive; a single queen and thousands of workers. The only reproductively active female ... -
(Thesis, Master of Science, 2013)Most streptococcal species are essentially non-pathogenic and are part of the normal commensal microflora of the mouth, skin, intestine, and upper respiratory tract of humans (and other animals). Streptococcus salivarius ... -
Human Sexual Dimorphism and Health During the Intensification of Agriculture in Prehistoric Thailand (Thesis, Doctor of Philosophy, 2013)The introduction and intensification of agriculture is regarded as a major transition experienced by humans. This period in prehistory provides a suitable framework to evaluate adaptation of the past populations to changes ...
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(Thesis, Master of Science, 2013)The gonadal steroid estradiol has widespread and diverse actions within the brain, although many of the cellular mechanisms responsible are unknown. This study extends a previous observation that estradiol can modulate ...
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(Thesis, Doctor of Philosophy, 2013)Magnesium (Mg) and its alloys were initially investigated as resorbable orthopaedic biomaterials more than a century ago. However, their use was abandoned due to rapid corrosion resulting in mechanical failure and excess ...
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(Thesis, Doctor of Philosophy, 2013)Members of the genus Mycobacterium are able to degrade cholesterol and for pathogenic members like Mycobacterium tuberculosis this degradation has been implicated in persistence in the lungs of the chronically infected ...
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(Thesis, Master of Science, 2013)Exposure to ethanol during the third trimester brain growth spurt can have detrimental effects. Damage to the central nervous system being the most severe outcome resulting from prenatal ethanol exposure causing a range ...
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(Thesis, Doctor of Philosophy, 2013)In cell-surface signalling pathways, the binding of an iron chelate to a specific outer membrane receptor induces gene expression in the cytoplasm via extra-cytoplasmic function sigma proteins. In these pathways gene ...
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(Thesis, Bachelor of Medical Science with Honours, 2012)Background: Few studies have attempted to define the intraosseous course of the chorda tympani (CT) a bilateral nerve that conveys taste from the anterior two-thirds of the tongue and provides parasympathetic innervation ...
Now showing items 1-20 of 237