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Search Results for Collection: School of Pharmacy

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Effect of bile salts on drug delivery to the brain

Yang, Lin (Thesis, Doctor of Philosophy, 2010)

Bile salts are endogenous surfactants which have been extensively studied as permeability enhancers to increase drug transport across various biological barriers such as the intestine, skin and buccal mucosa. However, only ...
Influence of the gut microbiota and probiotics on selenium metabolism in the rat: In vitro and in vivo studies

Krittaphol, Woravimol (Thesis, Doctor of Philosophy, 2011)

Selenium plays a major role in the immune system and in decreasing the risk of cancer. Plasma selenium levels are low in patients with certain gastrointestinal disorders suggesting a role for the gut microbiota in selenium ...
Optimal design methods that are robust to uncertainty

Foo, Lee Kien (Thesis, Doctor of Philosophy, 2012)

Assumptions are usually made when optimising design for an experiment. Unexpected departure from the assumptions may result in suboptimal design. This thesis aims to address the issue of optimal design under uncertainties. ...
Medicines in the context of older people's lives

Bagge, Michael (Thesis, Doctor of Philosophy, 2012)

Background: Older people often take a relatively high number of prescription medicines and experience a range of issues linked with these medicines. Older people admitted to hospital for an acute condition often experience ...
The effect of moisture during thermal treatment of directly compressed Eudragit ®RLPO matrices

Pirayavaraporn, Chompak (Thesis, Doctor of Philosophy, 2012)

Purpose: This thesis investigated of the effect of moisture on a polymeric matrix system. The effect of moisture on compaction and coalescence behaviours, which are major influences on drug release regulation, is of ...
Transcutaneous immunization using lipid colloidal systems and microneedles

Rattanapak, Teerawan (Thesis, Doctor of Philosophy, 2013)

Background: Needle-free immunization is a novel vaccination approach and provides many advantages over traditional vaccination. The present study focused on transcutaneous immunization (TCI) which is a promising approach ...
Physicochemical and biological characterisation of novel immunomodulators

Hubert, Madlen (Thesis, Doctor of Philosophy, 2013)

Native phosphatidylinositol mannosides (PIMs) isolated from the cell wall of mycobacteria, and synthetic analogues, have been reported to have the ability to both suppress and stimulate the immune system. These immunomodulating ...