Otago University Research Archive
Browsing School of Pharmacy by Date Published
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Browsing School of Pharmacy by Date Published
Now showing items 1-20 of 25
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(Thesis, Doctor of Philosophy, 2013)Background: Needle-free immunization is a novel vaccination approach and provides many advantages over traditional vaccination. The present study focused on transcutaneous immunization (TCI) which is a promising approach ... -
Evaluating Critical Quality Attributes of Modified Release Systems using Advanced Imaging Techniques (Thesis, Doctor of Philosophy, 2013)Combination of physical and chemical stability during storage, excellent content uniformity, simplicity of administration and economical manufacturing make solid dosage forms the pharmaceutical drug delivery systems of ...
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(Thesis, Doctor of Philosophy, 2013)Native phosphatidylinositol mannosides (PIMs) isolated from the cell wall of mycobacteria, and synthetic analogues, have been reported to have the ability to both suppress and stimulate the immune system. These immunomodulating ... -
(Thesis, Doctor of Philosophy, 2012)The overarching aim of this work was to utilise modelling and simulation methodology to obtain a better understanding of clinical data generated from or in red blood cells (RBCs). It focussed on RBC survival and the use ...
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(Thesis, Doctor of Philosophy, 2012)Assumptions are usually made when optimising design for an experiment. Unexpected departure from the assumptions may result in suboptimal design. This thesis aims to address the issue of optimal design under uncertainties. ... -
(Thesis, Doctor of Philosophy, 2012)The CAP protein superfamily comprises: the Cysteine-rich secretory proteins, Antigen 5 and the Pathogenesis Related group 1 proteins. Their diverse biological functions include mammalian reproduction (e.g. CRISP1-4) and ...
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(Thesis, Doctor of Philosophy, 2012)Bilosomes are a novel colloidal delivery system similar to niosomes but incorporating bile salts (BS) into the vesicular lipid bilayer membrane. Although of proven value in the delivery of antigens and vaccines, they have ...
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(Thesis, Doctor of Philosophy, 2012)Purpose: This thesis investigated of the effect of moisture on a polymeric matrix system. The effect of moisture on compaction and coalescence behaviours, which are major influences on drug release regulation, is of ... -
(Thesis, Doctor of Philosophy, 2012)Purpose: The broader application of self-nanoemulsifying drug delivery systems (SNEDDS) has been hampered by the limited solubility of lipophilic, hydrophobic drugs, often requiring the inconvenient dosing of multiple ...
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(Thesis, Doctor of Philosophy, 2012)Background: Older people often take a relatively high number of prescription medicines and experience a range of issues linked with these medicines. Older people admitted to hospital for an acute condition often experience ... -
(Thesis, Doctor of Philosophy, 2011)Selenium plays a major role in the immune system and in decreasing the risk of cancer. Plasma selenium levels are low in patients with certain gastrointestinal disorders suggesting a role for the gut microbiota in selenium ... -
(Thesis, Doctor of Philosophy, 2011)Risk assessment is a fundamental part of clinical toxicology. It is complicated due to a variable time course of clinical effects of drugs in clinical toxicology. Defining the time course of clinical effects of drugs in ...
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(Thesis, Doctor of Philosophy, 2011)Milling is a common pharmaceutical unit operation, which provides two possible pathways to enhance the dissolution rate of poorly water soluble drugs: particle size reduction and solid state form transformation. This thesis ...
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Influence of preparative techniques on the structure, stability and dissolution of amorphous drugs (Thesis, Doctor of Philosophy, 2011)Poorly soluble drugs are becoming increasingly common in the pharmaceutical setting. Such drugs often exhibit dissolution rate-limited absorption and therefore methods to increase the dissolution rate of such drugs are of ...
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(Thesis, Doctor of Philosophy, 2011)Purpose: The increasing interest in new generation vaccines is based upon utilising highly purified proteins and peptides as antigens. However, a disadvantage of these subunit vaccines is that they are often poorly ...
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(Thesis, Doctor of Philosophy, 2010)Bile salts are endogenous surfactants which have been extensively studied as permeability enhancers to increase drug transport across various biological barriers such as the intestine, skin and buccal mucosa. However, only ... -
(Thesis, Doctor of Philosophy, 2007)Background: In September 2001, in addition to their existing management of primary care pharmaceutical expenditure, PHARMAC, the New Zealand government's Pharmaceutical Management Agency, was authorized to manage pharmaceutical ...
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(Dissertation, Master of Clinical Pharmacy, 2007)
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Considerations in the use of cyclodextrins in the reformation of ophthalmic suspensions as solutions (Thesis, Doctor of Philosophy, 2000)
Now showing items 1-20 of 25