Otago University Research Archive
Browsing by Degree Name "Bachelor of Biomedical Sciences with Honours"
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Browsing by Degree Name "Bachelor of Biomedical Sciences with Honours"
Now showing items 1-20 of 29
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17α-hydroxylase and the androgen-treated sheep ovary – a model for Polycystic Ovary Syndrome (PCOS) (Thesis, Bachelor of Biomedical Sciences with Honours, 2012)Polycystic Ovary Syndrome (PCOS) is the most common cause of infertility in women of reproductive age, with an estimated five to ten percent of women worldwide affected by the endocrine condition. The aetiology of PCOS ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)The Transforming Growth Factor β (TGF β) superfamily is involved with regulating many biological and physiological processes. Activins are members of the TGF β superfamily. Four activin subunits (βA, βB, βC and βE) have ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2012)Background: The ulnar nerve is a major nerve in the upper limb and is susceptible to injury, particularly in the region of the cubital tunnel. A suspected mechanism of injury at this site is ischaemia. Whilst this can be ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Ankylosing Spondylitis (AS) is chronic inflammatory arthritis of spine and sacroiliac joints with further peripheral manifestations. AS is a relatively common rheumatic disease affecting 0.1- 1.4% of the population. Early ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2013)There is an increased incidence of dysfunctional mood disorders postpartum, affecting approximately 10-20% of all women. Postpartum mood disorders can have devastating effects on the mother, and lead to altered relationships ... -
Cardiac function and β-adrenergic receptor responsiveness in the isolated human diabetic myocardium (Thesis, Bachelor of Biomedical Sciences with Honours, 2012)The prevalence of type 2 diabetic mellitus is closely associated with cardiovascular complications. Diabetic patients with preserved ejection fraction (EF) are at high risk of developing heart failure. Until now, little ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Tuberculosis (TB) is a difficult to treat disease caused by the bacterium Mycobacterium tuberculosis. M. tuberculosis is able to shut down its metabolism in response to diverse environmental cues and enter a stage of ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2012)The Implanted Cardioverter Defibrillator (ICD) has emerged as one of the strongest therapeutic options for patients at high risk of SCD [65-67]. Despite this its high cost, in relation to other therapies, has made its use ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Abstract Increased cardiac sympathetic drive as a consequence of increased renal sympathetic activity is an important contributor to the development of cardiovascular complications in patients with diabetic nephropathy. ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Poxviruses are complex, large double stranded DNA viruses that replicate in the cytoplasm of infected cells. The early phase of infection involves a two step uncoating process, firstly releasing viral core structures, then ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)By presenting antigen to T cells dendritic cells (DC) carry out a central role in the activation of T cell mediated immunity to cancer. Tumour cell lysate (TL) as a source of tumour antigens offers the advantage over single, ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Telomeres are specialised structures, consisting of tracts of simple DNA sequence repeats that cap the ends of chromosomes. These structures play a vital role in maintaining the integrity of the genome and prevent the loss ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2012)Lipoprotein(a) [Lp(a)] is a plasma lipoprotein, characterised by an apo(a) molecule bound via a disulphide bond to apoB of a low density lipoprotein- (LDL-) like particle. Elevated Lp(a) levels are a well established risk ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2012)The adrenal medulla regulates the acute stress response and is itself controlled through a variety of signals, including neuronal, endocrine and paracrine factors. Additionally, recent literature suggests that adrenal ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Endogenous hydrogen sulfide (H2S) has recently been described as the third gaseous mediator of interest. It has been proposed in the literature [1] , that H2S has a role in inflammation, through the induction of upstream ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2011)Macrophage migration inhibitory factor (MIF) is a highly conserved regulatory cytokine, known to exert pro-inflammatory effects. MIF biological activity is primarily regulated via interaction with the CD74 receptor. MIF ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2012)Primary tumours are rarely lethal; instead most cancer deaths are due to the spreading of the tumour to other sites in the body (metastasis). One major pathway of metastatic disease is the migration of tumour cells from ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2012)Polycystic ovarian syndrome (PCOS) is the most common cause of infertility among women of reproductive age worldwide. Although the aetiology is unclear, there are a number of neuroendocrine disruptions which identify PCOS ... -
Maternal obesity predisposes offspring to obesity; understanding the role for elevated Interleukin-6 (Thesis, Bachelor of Biomedical Sciences with Honours, 2012)Obesity has quickly become an epidemic, and there has been a concomitant increase in the prevalence of obesity during pregnancy. Together human and animal studies have revealed that over-nutrition is a high risk factor ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2012)Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome caused by germline mutations in the CDH1 gene which encodes the calcium-dependent, cell-cell adhesion protein E-cadherin [1,2]. Early stage ...
Now showing items 1-20 of 29